Superbugs blamed on shoddy repairs

 作者:乔竺     |      日期:2019-03-08 05:09:01
BACTERIA that survive an antibiotic attack emerge stronger, with an ability to repel new drugs. The conventional idea is that susceptible bugs perish, leaving behind a few individuals whose drug resistance is passed on as they multiply. This does not, however, explain why bacteria treated with one drug tend to resist others too. Now Jim Collins at Boston University and his team have found that several different kinds of antibiotics can actively create mutations that confer this multidrug resistance. The antibiotics produce toxic molecules called free radicals that damage the DNA of Escherichia coli,